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AuthorOckner, Robert K. author
TitleIntegration of Metabolism, Energetics, and Signal Transduction [electronic resource] : Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease / by Robert K. Ockner
ImprintBoston, MA : Springer US, 2004
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Descript XVII, 387 p. 10 illus., 3 illus. in color. online resource


INTEGRATION OF METABOLISM, ENERGETICS, AND SIGNAL TRANSDUCTION Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease ROBERT K. OCKNER "Dr. Ockner has written a fascinating and original book which explores potential metabolic links to neurodegeneration. He takes a fresh look at metabolic pathways involving interaction between astrocyte and neuron that are important for brain health and may play a significant role in the pathogenesis of Alzheimer disease and other normal and pathological phenomena. Dr. Ockner has a distinguished research career in fatty acid metabolism and the fatty acid binding proteins and writes with clarity upon this under-explored aspect of the brain in health and disease. Not only is his book important for understanding links between systemic and cerebral metabolism in neurodegeneration, but is a must read for scientists with an interest in the connection between metabolic pathways and brain function." โ{128}{148} Dr. Bruce Miller, Professor of Neurology Clinical director of the Memory and Aging Center University of California, San Francisco "I find this book to be a commendable and comprehensive undertaking as it encompasses an evaluation of a wide area of scientific research. Researchers working in lipid metabolism to those interested in mitochondrial energetics and in the mechanisms of signal transduction pathways in cancer and Alzheimer disease will benefit from this book." โ{128}{148}M.A.Q. Siddiqui, Professor and Chairman of the Department of Anatomy and Cell Biology SUNY Downstate, Brooklyn, NY Robert K. Ockner, M.D. is Professor of Medicine at the University of California, San Francisco, and is former Director of the UCSF Liver Center and Division of Gastroenterology. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins. He is a graduate of the Harvard Medical School and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital. Cover art by Sadie McFarlane


Prologue -- Disparate Themes: Origins and Integration -- Fatty Acids, Mitochondria, and Signal Transduction: Integrated Control of Cell Proliferation, Injury, and Death -- to Part II -- Nutrient and Energy Metabolism in Cell Proliferation -- Fatty Acids and Growth Regulation -- Mitochondrial Function in Cell Growth and Death -- Metabolic Effects of Antiproliferative Agents -- Fatty Acids and Mitochondria, Cell Growth and Injury: Broader Implications -- Metabolism and Gene Expression in Liver Regeneration -- II Conclusions -- Fatty Acids, Ketone Bodies, and Brain Metabolism: Implications for Neuronal Function and Alzheimer Disease -- to Part III -- Energetics of Neuronal Activation -- Utilization of Oxidizable Substrates in Brain -- Astrocyte Metabolism and Astrocyte-Neuron Interaction -- Neuronal Energy Metabolism in Brain: Astrocyte as both Metabolic โ{128}{156}Bufferโ{128}{157} and Mediator of Neuronal Injury -- Pathogenesis of Alzheimer Disease: Metabolic Factors -- III Conclusions -- Epilogue -- Looking Back, Looking Ahead

Medicine Neurosciences Neurology Biochemistry Biological psychology Medicine & Public Health Neurology Biochemistry general Biological Psychology Neurosciences


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