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TitleSignal Transduction in Cancer [electronic resource] / edited by David A. Frank
ImprintBoston, MA : Springer US, 2003
Connect tohttp://dx.doi.org/10.1007/b101861
Descript VIII, 357 p. online resource

SUMMARY

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."


CONTENT

Receptors -- Growth, Survival and Migration: The Trk to Cancer -- The Role of Growth Factor Signaling in Malignancy -- TGF-? Signaling Alterations in Cancer -- Notch in Malignancy -- Intracellular Pathways -- cAMP Signaling in Cancer Genesis and Treatment -- PI3K/PTEN/Akt Pathway -- Wnt Signaling in Human Cancer -- Ras Signaling, Deregulation of Gene Expression and Oncogenesis -- Role of the RB Tumor Suppressor in Cancer -- Transcription Factors -- The Rel/NF-?B/I?B Signal Transduction Pathway and Cancer -- STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies -- Steroid Hormone Receptor Signaling in Cancer -- Cell Death Pathways -- Cell Death Signaling in Malignancy -- Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies


Medicine Cancer research Oncology Biomedicine Cancer Research Oncology



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