Author | Ohta, Tomoko. author |
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Title | Evolution and Variation of Multigene Families [electronic resource] / by Tomoko Ohta |
Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1980 |
Connect to | http://dx.doi.org/10.1007/978-3-642-93138-3 |
Descript | VIII, 136 p. online resource |
1 Organization and Properties of Antibody Genes and Other Multigene Families -- 1.1 Multigene family -- 1.2 Antibody gene families -- 1.3 Coincidental evolution -- 2 Models of Unequal Crossing-Over -- 2.1 Simulation studies of the model of unequal crossing-over -- 2.2 Diffusion approximation of coincidental evolution -- 2.3 Coincidental evolution as a birth-death process -- 3 Population Genetics Approach -- 3.1 Model -- 3.2 Approximate analyses by double diffusion process -- 4 Decrease of Genetic Correlation with Distance Between Gene Members on the Chromosome -- 4.1 Unequal crossing-over by shift of one gene unit -- 4.2 Unequal crossing-over by shift of more than one gene -- 4.3 Average identity coefficient -- 5 Genetic Differentiation of Multigene Families -- 5.1 Identity coefficient between the populations -- 5.2 Variance and covariance of identity coefficients -- 5.3 Numerical examples and some applications -- 6 Statistical Analyses on Sequence Variability of Immunoglobulins -- 6.1 Average identity coefficient -- 6.2 Identity coefficient in association with subfamilies of variable region sequences -- 6.3 Variance and covariance of identity coefficients -- 7 Linkage Disequilibrium Between Amino Acid Sites in a Multigene Family -- 7.1 Variance of linkage disequilibrium coefficients -- 7.2 Application to sequence variability of immunoglobulins -- 8 Prospects for Future Research -- 8.1 Gene conversion and other mechanisms to increase homogeneity -- 8.2 Non-constant gene family size -- 8.3 Accumulation of non-functional genes -- 8.4 Natural selection on gene diversity -- 8.5 Possible other examples to apply the theory -- 8.6 Multigene family of small size -- 8.7 Concluding remarks -- References