The Statistical Analysis of Pharmacokinetic Data -- Mathematical Methods in The Formulation of Pharmacokinetic Models -- New Approaches to Uptake by Heterogeneous Perfused Organs: From Linear to Saturation Kinetics -- Basic Principles Underlying Radioisotopic Methods for Assay of Biochemical Processes in Vivo -- Tracer Studies of Peripheral Circulation -- Tracer Kinetic Modeling in Positron Computed Tomography -- Pharmacokinetic Models and Positron Emission Tomography: Studies of Physiologic and Pathophysiologic Conditions -- Kinetic Analysis of the Uptake of Glucose and Some of Its Analogs in the Brain Using the Single Capillary Model: Comments on Some Points of Controversy -- The Use of 11C-Methyl-D-Glucose for Assessment of Glucose Transport in the Human Brain: Theory and Application -- The Indicator Dilution Method: Assumptions and Applications to Brain Uptake -- Measurement of Ligand-Receptor Binding: Theory and Practice -- Acknowledgements