Author | Knolle, Helmut. author |
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Title | Cell Kinetic Modelling and the Chemotherapy of Cancer [electronic resource] / by Helmut Knolle |
Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1988 |
Connect to | http://dx.doi.org/10.1007/978-3-642-45651-0 |
Descript | VIII, 157 p. online resource |
I. Mathematical models of cell populations -- 1. Proliferation and differentiation of cells -- 2. The cell cycle -- 3. The simple model of tumor growth -- 4. The extended model of tumor growth -- 5. Cell age distribution and phase indices -- 6. The general model with distributed cycle time -- 7. The Kendall-Takahashi model -- II. Determination of cell kinetic parameters -- Introduction: Cell kinetic experiments -- III. Cell kinetics and cancer therapy -- 1. The surviving fraction after a single dose -- 2. Phase-specific cell kill -- 3. Block of the cell cycle -- 4. Recruitment of resting cells -- 5. A complex mathematical model and computer programs -- 6. Implications for drug testing -- 7. Potential implications for therapy -- 1. Limit theorems for matrix models -- 2. A model with periodic parameters -- 3. Pharmacokinetics and the dose-effect relation -- List of symbols -- References