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AuthorBagshaw, C. R. author
TitleMuscle Contraction [electronic resource] / by C. R. Bagshaw
ImprintDordrecht : Springer Netherlands, 1982
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The student of biolo,gical science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably concerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background knowledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory textbooks or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook of biology. This outline then sets out to provide by building on this basis, the conceptual framework within which modern research work is progressing and aims to give the reader an indication of the problems, both conceptual and practical, which must be overcome if progress is to be maintained


1 Introduction -- 2 Gross anatomy and physiology -- 2.1 Muscle types -- 2.2 Physiological states -- 2.3 Activation -- 2.4 Physiological performance -- 2.5 Fuel and energetics -- 3 Muscle cells -- 3.1 Striated muscle -- 3.2 Sliding filament theory -- 3.3 Membrane systems -- 3.4 Fibre preparations -- 3.5 Unstriated muscle -- 4 Protein components -- 4.1 Proteins of the myofibril -- 4.2 Actin -- 4.3 Myosin -- 4.4 Actinโ{128}{148}myosin interactions -- 5 Mechanism of ATP hydrolysis -- 5.1 Kinetic analysis -- 5.2 Myosin ATPase -- 5.3 Actin activation -- 6 Molecular basis of contraction -- 6.1 What makes filaments slide? -- 6.2 Electron microscope studies -- 6.3 X-ray diffraction studies -- 6.4 Mechanical transients -- 6.5 Mechanochemical coupling -- 7 Molecular basis of regulation -- 7.1 Role of calcium -- 7.2 Actin-linked regulation -- 7.3 Myosin-linked regulation -- 7.4 Multiple regulatory systems -- 8 Problems and prospects -- References

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