ความเป็นพิษต่อเซลล์มะเร็งของพืชสมุนไพรไทยจากอุทยานแห่งชาติปางสีดา : รายงานการวิจัย = Cytotoxicity of medicinal plants from Pangsrida National Park / จรรยา ชัยเจริญพงศ์, ทรงจันทร์ ภู่ทอง, อณุมาศ บัวเขียว
40 Medicinal plants from Pangsrida National park were tested for cytCltoxicity against cancer cell line. 13 rv.iedicinal plants; Aoisamsuan (leaD, Kudkaopa (leaD, Makong (leaf and stem), Makongyai (leaD, Khaolam (leaD, Tasae (leaf and stem), Konteso (stem), Rangdon (leaD, Keawpum (leaD, Takopa (leaD, Khanang (fruit), Punchad (leaD and Plongkeekwai (leaD; were showed cytotoxicity against cancer cell line. Ethanol extract of Aglaia elaeagnoidea (A. Juss.) Benth. showed strongest cytotoxicity activity. It was separated to obtain 4 fraction; MKE4F-2 (8.S mg, 0.004% w/w of dried leaD, MKE4H-4 (2.6 mg, 0.001 % w/w of dried leaD, MKE4I-4 (11.6 mg, O.OOS% w/w of dried leaD and MKE6F-S (14.6 mg, 0.007% w/w of dried leaD from ethyl acetate extract. MKE4F-2 and MKE6F-S are S-hydroxy-6,7,8-trimethoxy-2-(4methoxyphenyl)-4H-chromen-4-one (S-demethyltangeretin) and triterpenoid, respectively but MKE4H-4 and MKE4I-4 are mixture. All of them showed strong cytoxicity against cencer cell line. MKE4F-2 showed strongest acti"ity against Chago cancer cell line with IC50 0.70 Ilg/ml, MKE4H-4 showed so strongest activity against Hep-G2, BT474 and KA TO-III with IC50 0.30, 3.28 and 0.06 Ilg/ml, so respectively. All of separated compounds showed strong activity against SW620 with IC50 < O.OOIIlg/ml, so less than IC50 of Doxorubicin 90 times. The results indicated that compounds extracted from A. so elaeagnoidea may be developed to be colon cancer drug in the future.