The purpose of thisdescriptive research was to examine1)hopelessnessamongelderly patientswith Major Depression and 2) the relationships betweenage,gender,religiousbelief / activities, stressfullifeevent ,depression, self–esteem , social supportsand hopelessness. ASample was156patientswith Major Depression, aged 60 years andolder, who wererandomly selected from the outpatient department at RatchaburiHospital,MakarakHospital,andPahonponpayuhasana Hospital. Theresearchinstruments were: 1) Personal Questionnaire, 2)Geriatric Social Readjustment Rating Scale (GSRRS), 3)Thai Geriatric Depression Scale(TGDS), 4)Self Esteem Scale,5) The personal resource questionnaire(PRQ85), and 6)Geriatric Hopelessness Scale(GSH). All instruments were verified for Content Validity Index (CVI > .80) by fiveexpertsandreliability of the 2rd – 6thquestionnairesbyCronbach’s alpha coefficient were .85, .79, .78, .73 and .77.Datawere analyzed by usingdescriptivestatistics, Eta Coefficient andPearson’ sProductMomentCorrelation. Theresults revealedthatthemeanscore of hopelessnesswas at themoderate level ( =15.87,±SD = 5.40).Stressfullifeevent, self – esteem, socialsupportwere statistically significant low negative correlation with hopelessnessamongelderlypatientswith Major Depression(r = -.200,p < .05, r = -.581, r = -.481,p< .01 respectively).Depression was statistically significantmoderate positive correlation withhopelessnessamongelderlypatientswithMajor Depression(r = .670, p < .01).