The purpose of this correlational research was to study depression and correlates of depression in patients with epilepsy including gender, social support, stigma, self-management, medication adherence and self-efficacy. The sample consisted of 90 epileptic patients both male and female who attended at epileptic clinic of King Chulalongkorn Memorial Hospital. The research instruments were: a demographic questionnaire, a social support questionnaire, a stigma questionnaire, a self-management questionnaire, a medication adherence questionnaire, a self-efficacy questionnaire, and a depression questionnaire. All instruments were tests for content validity by a panel of experts. The reliability of the instruments tested by Conbach’s Alpha were .83, .89, .78, .71, .89, and .77 respectively. Data were analyzed using mean, standard deviation, point biserial correlation, and Chi-square test. The major findings were as followed: 1.Most (62.2%) of the patients showed depression(X =18.62, SD=1.87) 2.Stigma (rpbis =.359) was positively significant related to depression at the level of .05 3.Social support(rpbis =-.211) and self-efficacy ( rpbis =-.405) were negatively significant related to depression at the level of .05 4.Gender, self-management, and medication adherence were not significantly related to depression at the level of .05.