การศึกษาความสัมพันธ์ระหว่างความหลากหลายทางพันธุกรรมของตัวรับของของฮอร์โมนเอสโตรเจนชนิดอัลฟ่าและการเกิดโรคหลอดเลือดหัวใจตีบของผู้ป่วยชายไทย ในโรงพยาบาลจุฬาลงกรณ์ / ดารกา โควินทเศรษฐ = Associaton between estrogen receptor α polymorphism and coronary heart disease in Thai male patients at King Chulalongkorn Memorial Hospital / Daraka Kowintasate
Background : Estrogens have favorable effects on the cardiovascular system. Their genomic effects are exerted via the estrogen receptor alpha (ERα) and beta (ERβ) which are expressed in endothelial cells and vascular smooth muscle cells. Polymorphisms of the estrogen receptors may be associated with cardiovascular disease. Objectives : To investigate the association between an ERα polymorphism (c.454-397T>C) with coronary heart disease in Thai male patients and other risk factors including diabetes mellitus, hypertension, dyslipidemia and obesity. Methods : A cross-sectional case-control study, 85 patients with more than 50% coronary stenoses (CAD group) and 85 patients with less than 50% coronary stenoses (control group). The c.454-397T>C genotype were determined by standard method of polymerase chain reaction and restriction fragment length polymorphism. Results : The frequency of the ERα c.454-397T>C polymorphism was similar in the CAD group and the control group (P-value = 0.18). In addition no association between ERα c.454-397T>C polymorphism and other diseases were demonstrated. Conclusions : The result indicates that the c.454-397T>C polymorphism of ERα is not associated with of coronary heart disease in Thai male patients.
