การศึกษาผลของยาโบเซนแทนต่อการเปลี่ยนแปลงของหลอดเลือดแดงปอดในกลุ่มหนูแรทที่อยู่ในสภาวะขาดออกซิเจนเป็นช่วงสลับกับสภาวะปกติอย่างต่อเนื่องเรื้อรัง / เอกฤทัย สุวรรณนาคินทร์ = Effect of bosentan on pulmonary vasculature in chronic intermittent hypoxic rat model / Akeruetai Suwannakin
Background This experimental study was designed to examine the effect of bosentan, endothelin receptor antagonist, on overall aspect of pulmonary vasculature in chronic intermittent hypoxic (CIH) rat model, an animal model of OSA. Methods Eighteen Wistar rats were divided into 3 groups. Rats in both CIH groups were exposed to alternating cycles of normoxia and hypoxia 8 h/day in light phase for 14 days and one CIH group was received bosentan 100 mg/kg/day. Results Neomuscularization of small pulmonary arterioles and right ventricular hypertrophy (RVH) were significantly increased in CIH group (p=0.042 and p=0.015). In bosentan-treated CIH group, significant reduction in mean pulmonary pressure and heart rate were found (p<0.001 and p=0.011). Conclusions CIH induces RVH and pulmonary vascular remodeling. The beneficial effect of bosentan for lessen pulmonary pressure suggests it as possible role in prevention and therapeutic option in OSA-associated pulmonary hypertension.