การศึกษาผลของยาราบีพราโซลที่มีต่อตัวแปรในการนอนหลับในผู้ป่วยที่มีภาวะกรดมากในหลอดอาหารร่วมกับกลุ่มอาการหยุดหายใจขณะหลับเปรียบเทียบกับยาหลอก / ธงชัย ลีลายุทธชัย = A randomized, placebocontrolled trial of rabeprazole on sleep parameters in patients with coexisting abnormal esophageal acid exposure and obstructive sleep apnea (OSA) / Thongchai Leelayuthachai
This randomized, double-blinded, placebo-controlled trial was performed to determine efficacy and rational use of proton-pump inhibitor in patients with coexisting abnormal esophageal acid-exposure and obstructive sleep apnea. 26 patients were enrolled and equally randomized into two arms of rabeprazole and placebo. Six weeks followed up with 24-hour ambulatory pH monitoring and polysomnography were done. Patients in rabeprazole group showed significantly reduction in apnea/hypopnea index (AHI) when compared with placebo group (p = 0.015). Rabeprazole also gave a reduction in respiratory disturbance index (RDI) and supine-RDI when compared with placebo. Dramatically reduced reflux parameters in rabeprazole group when compared with placebo.
