This research work covers the study of blood reserve management in Rajavithi Hospital. The main purpose of this study is to propose the invented measures required for a cost effective management of blood reserve unit and also to develop a manual for this blood reserve. The manual will describe ways to reduce wasted blood and unnecessary loss of blood in the process. The developed scenario of this study requires information collection regarding past blood demand at the hospital, assessing the collected information by using a computer program in statistic to investigate concern factor. The research proposed the method to forecast blood demand in next year by use the history data as two methods to support sufficient blood are the calculation table to see the demand blood used on surgery and the calculation on the preparation blood for surgery by use actual pass blood usage data. We found that the calculation table can forecast well when compared with the actual blood usage in follow year. Finally, we develop a manual work instruction to reduce long aging timing of return blood and suggest the ordering policy to deal with Thai Red Blood Cross center (TRC) and nearly hospital to Rajavithi Hospital. The design model indicates that there are essential causes affecting capital cost of the management of blood reserve namely, safety stock in blood bank and reorder point system level. The proposed measures could reduce capital cost of blood management by 5%.