Nonsteroidal anti-inflammatory drugs induce gastric injury. Curcumin, the active ingredient of Curcuma longa Linn., is a potent antioxidant and anti-inflammation. The present study determined the possible mechanism that curcumin could attenuate gastric injury induced by nonsteroidal anti-inflammatory drugs in rats. Male Sprague-Dawley rats were divided into three groups. Control group was fed olive oil 0.5 ml 30 minute prior to 5% NaHCO⁻₃ 1 ml at time 0th, 4th hr. NSAIDs group was fed olive oil 0.5 ml 30 minute prior to indomethacin (150 mg/kg BW day twice day) dissolved in 5% NaHCO⁻₃ 1 ml at time 0th, 4th hr. Pretreatment group was fed curcumin 200 mg/kg BW dissolved in olive oil 0.5 ml 30 minute prior to indomethacin 150 mg/kg BW dissolved in 5% NaHCO⁻₃ 1 ml at time 0th, 4th hr. After 8th hours 30 min, the leukocyte adherence of post-capillary venule in stomach was studied by intravital fluorescence microscopy then rats were sacrificed. The serum and stomach samples were collected at the end of the study. The stomach histopathology in indomethacin group showed multiple erosions with mild to moderate inflammation. Serum of ICAM-1 level and leukocyte-endothelium interaction increased significantly when compared with control group. Pretreatment with curcumin group resulted in decreasing the elevation serum of ICAM-1 level and leukocyte-endothelium interaction. In conclusion, curcumin could attenuate gastric injury induced by nonsteroidal anti-inflammatory drugs through the reduction of ICAM-1 level and leukocyte-endothelium interaction of gastric microcirculation.