1. Introduction / Rong (Ron) Liu -- 2. Solubility theories / Steven H. Neau -- 3. Prediction of solubility / Yisheng Chen, Xiaohong Qi, and Rong (Ron) Liu -- 4. Preformulation aspects of insoluble compounds / Wei-Qin (Tony) Tong and Hong Wen -- 5. Water-insoluble drugs and their pharmacokinetic behaviors / Honghui Zhou -- 6. Regulatory aspects of dissolution for low solubility drug products / Pradeep Sathe ...[et al.] -- 7. Formulation strategies and practice used for drug candidates with water-insoluble properties for toxicology, biology, and pharmacology studies in discovery support / Lian-Feng Huang ... [et al.] -- 8. Applications of complexation in the formulation of insoluble compounds / Wei-Qin (Tony) Tong and Hong Wen -- 9. Solubilization using cosolvent approach / Jay S. Trivedi -- 10. Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery: pt. 1. Parenteral aplications / John B. Cannon, Yi Shi, and Pramod Gupta -- 11. Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery: pt. 2. Oral applications / John B. Cannon and Michelle A. Long --