ฤทธิ์ลดน้ำตาลในเลือดของผงบอระเพ็ดแห้งในผู้ป่วยนอกกลุ่มอาการอ้วนลงพุงที่โรงพยาบาลจุฬาลงกรณ์ / ชุติมา ศรียาภัย = Hypoglycaemic effect of Tinospora Crispa dry powder in Outpatients with Metabolic syndrome at King Chulalongkorn Memorial Hospital / Chutima Sriyapai
The purpose of this study was to determine the hypoglycaemic effect of Tinospora crispa dry powder in patients with metabolic syndrome. A randomized placebo-controlled, crossover design was conducted at outpatient internal medicine clinic at King Chulalongkorn Memorial Hospital during October 2008 to March 2009. Thirty-six patients who met the NCEP III criteria guideline for metabolic syndrome were included and randomly assigned to receive 250 mg Tinospora crispa dry powder capsule or placebo twice a day for 2 months treatment period. It was found that patients who received Tinospora crispa dry powder had significantly decreased fasting blood glucose level from baseline (4.03±11.35 mg/dl, p = 0.027, median = 4.00 mg/dl, n = 36). Patients who received Tinospora crispa for the first 2 months also experienced reduced fasting blood glucose level statistically significant difference from baseline (6.29±10.47 mg/dl, p = 0.007, median = 8.00 mg/dl, n = 24). Adherence was assesses by pill count method. The results showed that 91.6% of patients adhered to Tinospora crispa. Seventy-two percent of the patients did not have significant differences of calories intake between Tinospora crispa and placebo groups. There was no statistically significant difference in the body weight between Tinospora crispa and placebo groups during the study period (p = 0.920). An elevation of more than 3 times baseline levels of aspartate aminotransferase and alanine aminotransferase was found in 16.7 % of samples