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TitleThe laboratory mouse [electronic resource] / edited by Hans J. Hedrich and Gillian Bullock
Imprint Amsterdam ; Boston : Elsevier Academic Press, c2004
Connect tohttp://www.sciencedirect.com/science/book/9780123364258
Descript xvi, 600 p. : ill

SUMMARY

Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimers, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project. One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model. * Edited by Hans Hedrich, Hannover Medical School * Comprehensive reference source written by international experts * Well-illustrated with high quality detailed images * Two-color, user-friendly format combined with color plate sections


CONTENT

History, Development and Genetics of the Mouse as a Laboratory Model -- Origin of the Laboratory Mouse and Related -- Historical Foundations -- Strain, Stock and Mutants -- Mouse Genomics -- Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis -- The Mouse as an Animal Model for Human Diseases -- The Mouse in Preclinical Safety Studies -- Anatomy and Developmental Biology -- Gross Anatomy -- Normative Histology of Organs -- Imaging -- Introduction to Early Mouse Development -- Pathophysiology (including non-infectious diseases) -- Skin and Adnexes of the Laboratory Mouse -- Cardiovascular System -- Respiratory Tract -- Gastrointestinal System and Metabolism -- Inbred Mouse Models for Autoimmune Disease -- Hematology of the Mouse -- The Social Behaviour of Mice and its Sensory Control -- Neuroendocrine Immune Network in Stress -- Circadian Rhythms of the Mouse -- Gerontology -- Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stock of Laboratory Mice -- Infectious Agents and Diseases -- Viral Infections -- Animal Husbandry and Production -- Housing and Maintenance -- Gnotobiology and Breeding Techniques -- Assisted Reproduction and Cryopreservation -- Health Monitoring -- Nutrition of Laboratory Mice -- Procedures -- Legal Regulations for the Protection of Animals Used for Scientific Experiments -- Necropsy Methods -- Handling and Restraint -- Routes of Administration -- Collection of Body Fluids -- Anaesthesia, Analgesia and Euthanasia


Mice Animals Laboratory Souris (Animal de laboratoire) Animais de laboratโorio. Ratos (anatomofisiologia) Ratos (genโetica) Mice as laboratory animals Electronic books.



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