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TitleThe Histamine H3 receptor [electronic resource] : a target for new drugs / edited by Rob Leurs and Henk Timmerman
Imprint Amsterdam ; New York : Elsevier, 1998
Edition 1st ed
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Descript xi, 291 p. : ill. ; 25 cm


In the early eighties when the H<INF>3</INF> receptor was identified, many thought that an H<INF>3</INF> ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.<P>The H<INF>3</INF> receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H<INF>3</INF> agonist and the H<INF>3</INF> antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.<P>In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H<INF>3</INF> receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H<INF>3</INF> paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H<INF>3</INF> receptor, especially as a target for drug development


Preface. Subclassification of histamine receptors, H<INF>3</INF>-receptor subtypes? Localization of H<INF>3</INF> receptors in the brain (J.M. Arrang <IT>et al.</IT>). Modulation of <IT>in vitro</IT> neurotransmission in the CNS and in the retina via H<INF>3</INF> heteroreceptors (E. Schlicker, M. Kathmann). H<INF>3</INF> receptor modulation of the release of neurotransmitters <IT>in vivo</IT> (P. Blandina <IT>et al.</IT>). H<INF>3</INF> receptor modulation of neuroendocrine responses to histamine and stress (U. Knigge <IT>et al.</IT>). Functional role of histamine H<INF>3</INF> receptors in peripheral tissues (G. Bertaccini <IT>et al.</IT>). Biochemical properties of the histamine H<INF>3</INF> receptor (M. Hoffman <IT>et al.</IT>). Radioligands for the histamine H<INF>3</INF> receptor and their use in pharmacology (F.P. Jansen <IT>et al.</IT>). Substituted imidazoles, the key to histaminergic receptors (W.M.P.B. Menge, H. Timmerman). Synthesis of radioligands for the histamine H<INF>3</INF> receptor (A.D. Windhorst <IT>et al.</IT>). Medicinal chemistry of histamine H<INF>3</INF> receptor antagonists (J.G. Phillips, S.M. Ali). Molecular modelling studies of histamine H<INF>3</INF> receptor ligands (I.J.P. de Esch <IT>et al.</IT>). Brain histamine in pathophysiological conditions and brain diseases (P. Panula <IT>et al.</IT>). Histamine H<INF>3</INF> antagonists as potential therapeutics in the CNS (K. Onodera, T. Watanabe). Clinical application of HA H<INF>3</INF> receptor antagonists in learning and memory disorders (C.E. Tedford)

Histamine -- Receptors Neurotransmitter receptors Receptors Histamine Receptors Neurotransmitter Electronic books.


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