Title | Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS [electronic resource] / edited by Swapan K. Chowdhury |
---|---|
Imprint | Amsterdam : Elsevier, 2005 |
Edition | 1st ed |
Connect to | http://www.sciencedirect.com/science/publication?issn=14643456&volume=6 |
Descript | xvi, 338 p. : ill. ; 25 cm |
Introduction: LC-MS and Drug Metabolism: A Journey Back in Time, Present Trends and Future Direction. -- Strategies for Increasing Throughput for PK Samples in a Drug Discovery Environment. -- Commonly Encountered Analytical Problems and their Solutions in Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) Methods Uded in Drug Development. -- Pitfalls in Quantitative LC-MS/MS: Metabolites Contributing to Measured Drug Concentrations. -- In <IT>vitro</IT> DMPK Sreening in Drug Discovery, Role of LC-MS/MS. -- Metabolite Identification by LC-MS: Applications in Drug Discovery and Development. -- Screening for the Assessment of Electrophilic Metabolite Formation Early in Drug Discovery Using HPLC-MS. -- Liquid chromatography Tandem Mass Spectrometry-Based Metabolite Identification Strategies in Pharmaceutical Research. -- Quantification and Structural Elucidation of Low Quantities of Radiolabeled Metabolites Using Microplate Scintillation Counting (MSC) Techniques in Conjunction with LC-MS. -- -- Oxidative Metabolites of Drugs and Xenobiotics: LC-MS Methods to Identify and Characterize in Biological Matrices. -- Detection and Charactrization of Highly Polar Metabolites by LC-MS: Proper Selection of LC Column and Use of Stable Isotope Labeled Drug to Study Metabolism of Rabavirin in Rats. -- Cytochrome P450 (CYP) and UDP-Glucuronosyltransferase (UGT) Enzymes: Role in Drug Metabolism, Polymorphism, and Identification of their Involvement in Drug Metabolism