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AuthorGreaves, P. (Peter)
TitleHistopathology of preclinical toxicity studies [electronic resource] : interpretation and relevance in drug safety evaluation / Peter Greaves
Imprint Amsterdam ; New York : Elsevier Science B.V., c2000
Edition 2nd ed
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Descript viii, 900 p. : ill. (some col.) ; 25 cm


This book describes histopathological assessment of preclinical toxicology studies that are conducted to assess the safety of novel drugs. It discusses the implications of drug-induced changes that may be relevant to the critical early stages of the development of new therapeutic agents, notably prior to their first administration to humans and during early clinical trials.<P> Covering virtually all aspects of drug-induced pathology in preclinical toxicity studies, the book is termed the 'gold standard' in the illustration of histopathology. This second revised edition continues to fill the gap for pathology literature relating to the development of new medicines and assessment of their safety based on preclinical studies. In addition to the updated references this edition contains many older references, some out of reach of modern computer based search tools


Preface to second edition. -- Chapter I.Integumentary System. -- Skin and subcutaneous tissue. -- Chapter II.Mammary Gland. -- Chapter III.Haemopoietic and Lymphatic Systems. -- Blood/bone marrow. -- Lymphoid system. -- Lymph nodes. -- Spleen. -- Thymus. -- Lymphoreticular neoplasms. -- Chapter IV.Musculoskeletal System. -- Bone. -- Joints. -- Skeletal muscle. -- Chapter V.Respiratory Tract. -- Nose, nasal sinuses, nasopharynx and pharynx. -- Larynx and trachea. -- Bronchi and lungs. -- Chapter VI.Cardiovascular System. -- Heart and pericardium -- Systemic blood vessels -- Pulmonary blood vessels -- Chapter VII.Digestive System 1. -- Forestomach. -- Stomach (glandular). -- Small intestine. -- Large intestine. -- Chapter VIII.Digestive System 2. -- Liver. -- Bile ducts, biliary system . -- Pancreas. -- Chapter IX.Urinary System. -- Kidney. -- Urinary bladder. -- Chapter X.Male Genital Tract. -- Prostate gland. -- Epididymis. -- Testis. -- Chapter XI.Female Genital Tract. -- Vagina. -- Cervix. -- Uterus. -- Ovary. -- Chapter XII.Endocrine System. -- Pituitary gland. -- Adrenal gland. -- Thyroid gland. -- Parathyroid gland. -- Chapter XIII.Nervous System and Special Sense Organs. -- Brain. -- Spinal cord, spinal nerve roots, peripheral nerves. -- Eye. -- Ear. -- Subject index

Drugs -- Toxicity testing Laboratory animals -- Histopathology Drug Evaluation Preclinical Animals Laboratory Histology Pathology Electronic books.


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