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TitleHigh throughput analysis for early drug discovery [electronic resource] / edited by James N. Kyranos
Imprint Amsterdam ; Boston : Elsevier, 2004
Edition 1st ed
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Descript xv, 186 p. : ill. (some col.) ; 24 cm


This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity. First reference to focus on the analytical side of synthesis


High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags, Adolor Corporation. -- Analysis of a Combinatorial Library Synthesized Using a Split-and-pool Irori MicroKan Method for Development and Production, Boehringer Ingelheim Pharmaceuticals, Inc. -- High-Throughput Mass Spectrometry-Flow Injection Analysis, Procter and Gamble Pharmaceuticals. -- High-Throughput Flow-Injection ESI and APCI Mass Spectrometry for Combinatorial Chemistry: Automated Acquisition and Interpretation for Multi-Sprayer Low-Resolution and FTMS High-Resolution Exact-Mass Measurements, Wyeth Research. -- Purity and Quantity Determination of Parallel Synthesis Compound Libraries, ArQule, Inc. -- High-Throughput Parallel LC/MS/ELSD of Combinatorial Libraries Using the Eight-Channel LCT System With MUX Technology, Nereus Pharmaceuticals Inc and University of California, San Diego. -- -- Purification and Analysis of Parallel Libraries, Albany Molecular. -- Screening Single Bead Combinatorial Libraries Using Capillary HPLC and MALDI-TOF-MS, National Research Council. -- The Role of NMR in the Analysis of Chemical Libraries, Bristol Meyers Squibb

High throughput screening (Drug development) Combinatorial chemistry Combinatorial Chemistry Techniques -- methods Drug Evaluation Preclinical -- methods Pharmaceutical Preparations -- analysis Electronic books.


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