Author | Fleisch, Herbert |
---|---|
Title | Bisphosphonates in bone disease [electronic resource] : from the laboratory to the patient / Herbert Fleisch |
Imprint | San Diego : Academic Press, c2000 |
Edition | 4th ed |
Connect to | http://www.sciencedirect.com/science/book/9780122603716 |
Descript | xii, 212 p. : ill. ; 24 cm |
Bone and Mineral Metabolism: -- Bone Physiology: -- Morphology. -- Composition of bone. -- Modeling and remodeling. -- Calcium homeostasis. -- Bone as an organ. -- Assessment of bone turnover. -- Bisphosphonates-Preclinical: -- Background to the pharmacological development: -- Chemistry. -- Actions. -- Physicochemical effects. -- Biological effects. -- Inhibition of bone resorption. -- Inhibition of mineralization. -- Pharmocokinetics: -- Intestinal absorption. -- Distribution. -- Renal clearance. -- Other modes of application. -- Animal toxicology: -- Acute toxicology. -- Nonacute toxicology. -- Bisphosphonates-clinical: -- Introduction. -- Paget's Disease: -- Definition. -- Epidemiology. -- Pathophysiology. -- Clinical manifestations. -- Treatment with drugs other than bisphosphonates. -- Treatment with bisphosphonates. -- Osteolytic tumor-induced bone disease: -- Definition. -- Pathophysiology. -- Clinical manifestations. -- Treatment with drugs other than bisphosphonates. -- Treatment with bisphosphonates. -- Non-tumor induced hypercalcemia: -- Definition. -- Pathophysiology. -- Clinical manifestations. -- Treatment with drugs other than bisphosphonates. -- Treatment with bisphosphonates. -- Osteoporosis: -- Definition. -- Epidemiology. -- Pathophysiology. -- Clinical manifestations. -- Treatment with drugs other than bisphosphonates. -- Treatment with bisphosphonates. -- Heterotopic calcification and ossification: -- Definition. -- Pathophysiology. -- Clinical manifestations. -- Treatment with drugs other than bisphosphonates. -- Treatment with bisphosphonates. -- Other diseases: -- Adverse events: -- Bisphosphonates in general. -- Individual bisphosphonates. -- Contraindications. -- Future prospects. -- Commercially available bisphosphonates: -- Index