Manganese accumulation and reduction from synthetic wastewater study on Spirulina (Spirulina platensis) obtained from Institute of Food Research and Product Development, Kasetsart University was able to accumulate manganese.Spirulina was cultured เท Zarrouk’s medium under the light intensity of 10,000 lux at room temperature with aeration. Initial manganese concentration at 16 mg/l and 32 mg/l inhibited the growth of spirulina. The suitable concentration of manganese for growing Spirulina was 8 mg/l at specific growth rate of 0.336. Accumulation of Mn by Spirulina platensis was the highest at pH 9 and manganese concentration of 4 mg/l, The highest manganese absorption capacity was 20.32 ug/mg dry weight. The specific uptake rate was 4.06 ug/minute. mg dw. Spirulina accumulated manganese rapidly within 5 minutes after that The uptake rate was slow and ended when manganese in the cell was 30 ug/mg dw. Spirulina has high nutrition compose of 63 - 68% protein of dry weight. Thus, spirulina which has manganese accumulation can be used for mixing in animal feed. This experiment,spirulina which cultured in initial concentration of manganese 8 mg/l at pH 9, had an absorption capacity was ug Mn/mg dry weight.