This research investigated the anxiey, social support and coping strategies of fourth-years university students. Participants were 679 undergraduate students from Chulalongkhon University. The instruments used were the State and Trait Anxiety Inventory (STAI Form-Y), the Social Support Questionnaire and the Coping Scale. Data was analyzed using a two-way ANOVA design followed by post-hoc multiple comparisons with Dunnett's T3 test and Pearson correlation coefficient. The major findings were as follows: 1. Fourth-year university students reported mild state and trait anxiety, used more problem-focused and social support-seeking strategies and used moderately low avoidance strategies. 2. Fourth-year university students obtained high emotional, information and total social supports and obtained moderately high appraisal and material supports. The students obtained high social supports from their mothers, fathers and friends. 3. Female students obtained more emotional, information and total social supports, used more social support-seeking strategies and used less avoidance strategies than male students. 4. Social science students reported higher state anxiety than physical science, biological science and humanity students. 5. Physical science students obtained less emotional support and used less social support-seeking strategies than biological science, social science and humanity students; obtained less appraisal and total social supports than social science and humanity students and obtained less material support than humanity students. 6. Students lived on campus reported less state and trait anxiety and used more problem-focused strategies than those living at home, and used less social support-seeking strategies than those loved off campus. 7. Students resided in up-country reported less state anxiety and obtained more emotional and material supports and used more problem-focused strategies than those resided in Bangkok. 8. Anxiety was negatively related to social support and problem-focused strategies, and positively related to avoidance strategies, but there was no significant relationship between avoidance strategies and social support.9. The correlation coefficient indicated significantly positive correlation among problem-focused strategies, social support-seeking strategies and social support.