Fenton’s reagent is a powerful oxidizing agent. It shows highly efficient treatment of hazardous organic contaminants contaminated in groundwater and wastewater. The treatment efficiency is obtained by treatment at the optimum condition. The optimum condition is recommended to be studied through the laboratory experiments before being implemented to the real treatment plant. The optimum condition was studied by varying the ratio of chemicals that form Fenton’s reagent; H2O2 and Fe2+ and TCE. The study was also carried by adding the titanium dioxide (TiO2) for increasing the rate of Fenton’s reaction to treat the wastewater. In addition, recycling of iron and TiO2 sludge for wastewater treatment was also studied. The economic was evaluated base on the treatment efficiency at the optimum conditions and ratio of initial substances. The results showed that at the optimum molar concentration ratio of H2O2:Fe2+:TCE is 20:2:1. However, enhancement of the treatment by TiO2 was insignificant. The results of recycling of the reagents showed satisfying result.