The research project aimed to analyze and develop computer program. It is created to be use for finding a suitable situation for sequencing the operation of chiller which have a different size. This project has chosen the chiller plant for Vidhayaborikhan Building, which located in Chulalongkorn University. The process that has been use in this project is divided into 2 parts. For the first part, we studied the characteristics and collect present information of the chiller individually. And use the information that we got to introduce in the form of mathematical model, and use it to develop into computer program in order to calculate, the spilling load of the chiller for the whole system. For the second part, we will collect an information from real time monitoring then use an information that we collected and send them to a computer program that we develop in the first part. We calculate the spilling work load and make it appropriate for the system at that specific time, and use the result to change the chiller system in order to make them appropriate right away. From the observation of a chiller by using computer program, we can conclude that computer program will find some changes in the splitting of the total load. The program will split higher load from the less efficient one. From that, we will find that the sequence of this effect will increase the energy saving of both chillers, which will reduce the kW/TON of both chillers. Consider the whole chiller system, we found that by using a computer program, it will increase an energy saving for the whole system as well.