วาโสแอกทีฟอินเทสทินอลเป็บไทด์กับการเกิดกลุ่มอาการ เฮปปาโตพัลโมนารีในผู้ป่วยเด็กที่เป็นโรคตับเรื้อรัง / ศิรินุช อำไพ = Vasoactive intestinal peptide and occurrence of hepatopulmonary syndrome in children with chronic liver disease / Sirinuch Ampai
To compare level of serum vasoactive intestinal peptide in children with chronic liver disease with and without hepatopulmonary syndrome. Design : Cross-sectional analytic study. Setting : Department of pediatrics, Chulalongkorn Hospital. Patients : Children with chronic liver disease age 0-15 years who had been followed up at Chulalongkorn Hospital between 1 March 2000 and 7 February 2001. Methods : History taking, physical examination, oxygen saturation were recorded. Contrast enhanced echocardiograpy (CE echo.) was performed by pediatric cardiologist, and was reviewed by another two pediatric cardiologists. Hepatopulmonary syndrome (HPS) was diagnosed by positive delayed opacification of microbubbles in left cardiac chamber. Serum vasoactive intestinal peptide (VIP) was measured by radioimmunoassay (RIA). Normal children without liver disease whose match for age and sex were used as a control group. Results : Forty-two children with chronic liver disease were underwent CE echo. HPS was diagnosed in 14 children (33%). Serum VIP levels of children with chronic liver disease were significantly higher than normal children (mean 60.21+-35.04 pg/mlv.s.43.71+-34.61 pg/ml p = 0.033). Children with HPS had higher serum VIP levels as compared to children without HPS (mean 72.65+-40.31 pg/ml v.s. 53.99+-31.0 pg/ml), but no statistically significant (p = 0.306) Conclusions : Although children with chronic liver disease had high level of serum vasoactive intestinal peptide but it may not be main mediator involved in occurrence of hepatopulmonary syndrome.