การศึกษาเปรียบเทียบการตอบสนองของผู้ป่วย ที่ได้รับการรักษาเพื่อลดขนาดของก้อนเดี่ยวชนิดแข็งของต่อมธัยรอยด์ด้วยยาลีโวไทรอกซินและยาหลอก / จิระพงค์ อุกะโชค = A comparative study of the response of patients with bening solid solitary thyroid nodule after treatment with levothyroxine versus placebo / Chirapong Ukachoke
Background : Solid solitary thyroid nodule is a common problem. The benefit of the current treatment with levothyroxine is still controversial. The literatures report conflicting results. Objective : To compare the influence of levothyroxine with placebo on reduction of thyroid nodular volume determined by ultrasonography and the proportion of responders who have nodular volume reduction by more than 50% between the study groups. Patients and Method : 39 female and 3 male patients with solid solitary thyroid nodule. Participated in this experimental randomized controlled trial study. 22 patients were allocated to levothyroxine treatment and 20 to placebo group. Thyroid nodular volume were determined by ultrasonography at 3 points in the study, each of which is 3 mohths apart. Results : In levothyroxine group, thyroid nodular volume decreased by 24.1%. In placebo group, thyroid nodular volume increased by 10%. The proportion of responder in treatment group is 4.5% and in placebo group is 5%. There are no statistically significant difference in these parameters between the two groups ( p>0.05). Conclusion : Levothyroxine shows no effective treatment in reduction of thyroid nodule volume when compared to placebo after treatment period of 6 months.