Helicobacter pylori : physiology and genetics / edited by Harry L. T. Mobley, George L. Mendz, Stuart L. Hazell
Imprint
Washing, DC : ASM Press, 2001
Edition
First edition
Descript
xvii, 608 pages : illustrations ; 28 cm
CONTENT
I. Introduction : Overview ; Epidemiology of infection ; One hundred years of discovery and rediscovery of helicobacter pylori and Its association with peptic ulcer disease -- II. Bacteriology : Basic bacteriology and culture ; Taxonomy of the helicobacter genus ; Morphology and ultrastructure ; Cell envelope ; Molecular structure, biosynthesis, and pathogenic roles of lipopolysaccharides ; Vacuolating cytotoxin -- III. Energy metabolism and synthetic pathways : Microaerobic physiology: aerobic respiration, anaerobic respiration, and carbon dioxide metabolism ; Nitrogen metabolism ; The citric acid cycle and fatty acid biosynthesis ; Nucleotide metabolism ; Biosynthetic pathways related to cell structure and function ; Evasion of the toxic effects of oxygen -- IV. Physiology and molecular biology : Urease ; Ion metabolism and transport ; Metabolite transport ; Protein export ; Alternative mechanisms of protein release ; Motility, chemotaxis, and flagella ; Natural transformation, recombination, and repair ; Chromosomal replication, plasmid replication, and cell division ; Restriction and modification systems ; Regulation of urease for acid habitation ; Transcription and translation -- V. Genetics : The genome ; Genetic exchange ; Gene regulation ; Mutagenesis ; The cag pathogenicity island ; Population genetics ; Heterogeneity and subtyping -- VI. Bacterial virulence and pathogenic mechanisms : Adherence and colonization ; Lipopolysaccharide lewis antigens ; Gastric autoimmunity ; Vaccines -- VII. Pathogenesis in the host, diagnosis, and treatment : Pathology of gastritis and peptic ulceration ; Host inflammatory response to infection ; Gastric cancer ; Markers of infection ; Antibiotic susceptibility and resistance -- VIII. Animal models and other helicobacter species : Enterohepatic helicobacter species ; Other gastric helicobacters and spiral organisms ; In vivo modeling of helicobacter-associated gastrointestinal diseases ; In vivo adaptation to the host