ประสิทธิภาพของการใช้ยาทาเคลือบเล็บ 8% ciclopirox olamine วิธีใหม่เปรียบเทียบกับการทายาวันละ 2 ครั้งในการรักษาโรคเชื้อราที่เล็บมือ / ภาวาส เทียมเศวต = The effectiveness of new method of applying 8% ciclopirox olamine nail lacquer compared to previous twice daily application in the treatment of fingernail onychomycosis / Pawas Tiamsavet
Onychomycosis is a common problem found in general practice. Presently, there have been many treatment developed, besides oral antifungal agents, which are the most commontly used, including surgical procedure and topical agents. Nowadays, topical agents have been developed for proper usage and convenience. 8% ciclopirox olamine nail lacquer is a broad-spectrum antifungal agent. This drug is found in layers of nail plate in concentration that is high enough to inhibit the growth of Trichophyton mentagraphytes. The concentration of the drug is gradually increased and reaches peak level at day 30 after application. The drug can also be detected in nail plate after stop using for 7-14 days. The objective of this study is to determine the effectiveness of 8% ciclopirox olamine nail lacquer in clinical and biological aspects. The new method (applying once a day in the first month, once a day on Monday and Thursday in the second month and once a day only on Monday in the third month) and the previous method of drug administration (applying twice daily for 3 months) is being compared. According to study on the previous method of application, improvement rate of onychomycosis is 87 percent. If the new method can produce the same improvement rate or differ not more than 20 percent, the new method may be considered as appropriate for clinical use. The result of this study shows that the average rate of increasing proportion of intact nail to total nail between 2 groups is not statistically significant. KOH preparation after treatment between 2 groups is also not statistically significant. From this study, we conclude that the new method of applying 8% ciclopirox olamine nail lacquer in patients with onychomycosis can produce the same improvement rate not differing from the previous method. This new method can be considered as the alternative means for treating patients with fingernail onychomycosis