This investigation was to study the synthetic route of amide derivatives ofvalproic acid, which were expected to possess anticonvulsant activity. The formation of N{2-propylpentanoyl)-L-proline proceeded by reacting2-propylpentanoyl chloride with amino acid in 10% sodium hydroxide solution. Thesynthetic route of N{2-propylpentanoyl)-L-proline ethyl ester,N{2-propylpentanoyl)-DL-serine methyl ester, N{2-propylpentanoyl)-DL-serine ethylester, and N{2propylpentanoyl)-glycine ethyl ester involved esterification of theamino acid with the corresponding alcohol in the presence of thionyl chloride, thenfollowed by the acylation with 2-propylpentanoyl chloride in the presence oftriethylamine. The synthetic route of N-(2-propylpentanoyl>L-proline benzylamide,N(2-propylpentanoyl)-DLserine benzylamide, and N(2-propylpentanoyl)-glycine benzyla,mide involved coupling of the N(2propylpentanoy0-amino acid with benzylamine in thepresence of N,N -dicyclohexylcarbodiimide. The synthetic route ofN(2-propylpentanoyl)-DL-serine involved basic hydrolysis ofN(2-propylpentanoyl)-DL-serine methyl ester. The synthetic route of N-hydroxymethyl-2-propylpentamide involved amidation of2-propylpentanoyl chloride by concentrated ammonia solution to yield2-propylpentamide, followed by the reaction with 37% formaldehyde in the presence ofpotassium carbonate. The synthesis of N-acetoxymethyl-2-propylpentamide involvedacetylation of N-hydroxymethyl-2-propylpentamide with acetic anhydride. The syntheticroute of N-methoxymethyl-2-propylpentamide involved N-alkylation ofN-2-propylpentamide with methoxymethyl chloride using sodium hydride as a base. The structures of the synthesized compounds were confirmed by infraredspectrometry, proton-1, and carbon-13 nuclear magnetic resonance spectrometry, massspectrometry, and elemental analysis techniques.