ผลของ CU763-14-08 และ CU763-14-11 ต่ออัตราการเต้นและแรงบีบตัวของหัวใจห้องบนขวาและซ้ายที่แยกจากหนูขาว / นิตยา เยินสูงเนิน = Effects of CU763-14-08 and CU763-14-11 on rate and force of contraction of isolated right and left rat atria / Nittaya Yoensungnoen
The effects of CU763-14-08 and CU763-14-11 (1x10 -4 M) were carried out upon the rate and force of contraction of isolated right and left rat atria. The result showed that CU763-14-08 and CU763-14-11 significantly increased the rate and force of contraction of isolated rat atria. These effects inhibited by propranolol (1x10 -6 M) and also by pretreated rats with reserpine (5 mg/kg/day, IP, 2 day). These results suggested that the positive chronotropic and inotropic effects of CU763-14-08 and CU763-14-11 may involve beta-adrenergic activity and also depend on catecholamine storage in the vesicles. Amitriptyline reduced potentiation effect of CU763-14-11 more than CU763-14-08. Also CU763-14-11 showed potentiation effect of tyramine, but not found in CU763-14-08.