Molasses are main raw material for fermentation in liquor industries. At present the quality of molasses become deteriorative. The solid quantities in molasses are high such as Ca 2+ = 13,000 ppm, SiO2 = 22,000 ppm, SO4 2- = 18,000 ppm and PO4 3- = 1,800 ppm. Calcium salts are the major contribution to the deposits of hard scale in pipelines and heating equipment such as heat exchanger, distillation column, heater, and evaporator. Consequently, the plant cannot increase the production. For molasses pretreatment, calcium removal, before feeding to the process, is considered to be beneficial for the downstream process. In this work, three approaches were investigated: mechanical method, chemical and mechanical method, and ion exchange method. The results show that the mechanical method can remove calcium approximate 20%, the chemical-mechanical method can remove approximate 94%, and the ion exchange method can remove approximate 96%. In order to make selection between the last two methods. From simulation with SuperPro Designer program version 2.7, it is shown that the chemical and mechanical is the appropriate method to be implemented in the industry.