การศึกษาถึงผลของยาฉีดที่ผลิตในประเทศไทย ต่อความเข้ากันไม่ได้ของยาผสมที่ให้ทางหลอดเลือดดำ / วิไลลักษณ์ จันทรกุลพงศา =Study of the effect of intravenous injections manufactured in Thailand on the incompatibility of admixtures
The purpose of this study was to determine the incompatibilities between drugs which were manufactured in Thailand and the large volume parenteral vehicles which might decrease the therapeutic efficacy or might be hazard to the patient. The selected drugs in this research were ampicillin sodium injections, penicillin G sodium injections, chloramphenicol sodium succinate injections, gentamycin sulfate injections, lincomycin hydrochloride injections, hydrocortisone sodium succinate injections and dexamethasone sodium phosphate injections. The large volume parenteral vehicles used in this study were 0.9% normal saline, 5% dextrose in water, 5% dextrose in 0.9% saline, 5% dextrose in half strength saline and lactated ringer’s solution which were made by Abbott Laboratories (Thailand) Ltd. After the drugs were added to the large volume parenteral vehicles any changes in color, precipitation formation, gas formation and changes in pH were observed immediately, and at 30 minutes, 3,6,8 and 24 hours after mixing at 30 – 31℃ and 8 - 10℃. The results of the study indicated that some of dexamethasone sodium phosphate injections and penicillin G sodium injections were incompatible with the large volume parenteral vehicles. The first were incompatible with all five large volume parenteral vehicles used in this study at both 30 – 31℃ and 8 – 10℃. The latter were incompatible with 0.9% normal saline at 30-31℃, 5% dextrose in water, 5% dextrose in 0.9% saline, and 5% dextrose in half strength saline at 30-31℃ and 8-10℃. Ampicillin sodium injections, chloramphenicol sodium succinate injections, gentamycin sulfate injections, lincomucin hydrochloride injections and hydrocortisone sodium succinate injections were compatible with all five large volume parenteral vehicles, except some products of gentamycin sulfate injections were incompatible with lactated ringer’s solution.