In the production of copolymer vinyl chloride-vinyl acetate, paint industry and many other processes, vinyl acetate residue often leaves the process in the effluent stream. In order to elimate the toxic residual vinyl acetate that is harmful to humans and aquatic animals and affect the environment, it is necessary to separate it from the waste water before draining to the public water source. Stripping of volatile organic solvent by air stripping in packed column have been used in various industries and waste water treatment processes. In this research, various factors influencing the separation of vinyl acetate from water by air stripping in packed column were investigated. The factors were air to liquid volumetric flowrate ratio, air and liquid intake temperature, packing height and mass transfer in stipping column. Results showed that the most appropriate air to liquid volumetric flowrate ratio was 366 and this ratio was directly proportional to the mass transfer and efficiency of the column. Moreover, it was found that the air and liquid intake temperature directly infulenced the mass transfer and efficiency of the column, but the height of the column had no influence on the efficiency of the column nor on the mass transfer.