ผลของไซโคลเด็กตรินที่ได้จากธรรมชาติและไดเมทิลบีต้าซัยโคลเด็กตริน ที่มีต่อค่าการละลายและคุณสมบัติทางเคมีฟิสิกส์ ของระบบการกระจายตัวของอินโดเมธาซิน / วาสินี มั่นจิตจันทรา = The influence of natural cyclodextrins and dimethyl-Beta-cyclodextrin on the dissolution and physicochemical properties of indomethacin dispersed systems / Vasinee MunjitJuntra
The dissolution characteristics and physicochemical properties of indomethacin(IDM) when incorporated with various cyclodextrins(CDS) as carries i.e. α-, β-, γ-cyclodextrin(CD) and 2,6-di-0-methyl-β-cyclodextrin(DIMEB) were investigated. The dispersed techniques used were grinding, kneading and solvent method. The ratio of drug and CDS were prepared in the ratio 1:0.5, 1:1, 1:2, 1:3, 1:6, 1:10. The dissolution rate of the drug increased as the ratio of carrier to drug was increased. And from three dispersion methods and four CDS used, DIMEB produced a significant increase in the dissolution rate of indomethacin. Then, the DIMEB dispersed systems were selected to prepare capsule and the dissolution profile with the corresponding mixture powders were also studied. DTA thermograms, IR spectra and X-ray diffractions revealed the polymorphic transition of IDM from Form I to Form III or Amorphous Form in the DIMEB dispersed systems and some interaction occurred that might be partially inclusion complex in the β-CD and γ-CD systems. Furthermore, SEM showed that size reduction appeared in all IDM dispersed systems. The increasing in wettability, and IDM dissolved in the addition of CDS from the phase solubility diagrams were also observed. The polymorphic conversion from high energy to the low ones (polymorph I or II) may occurred when incorporated with some diluents used in the capsule formulation that could caused the retardation in the dissolution of some cases of the prepared capsules.
