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AuthorDeeg, H. Joachim. author
TitleA Guide to Blood and Marrow Transplantation [electronic resource] / by H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips, Gary Van Zant
ImprintBerlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1999
Edition Third Completely Revised Edition
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Descript XII, 231 p. online resource


This book provides an introduction to marrow and peripheral blood stem cell transplantation (including cord blood transplants), emphasizing the principles of this rapidly evolving area. A brief historical perspective is given and the latest developments are discussed. Particular attention is given to the rationale and indications for transplantation, the selection of donors and source of stem cells, and the separation, expansion and manipulation of stem cells. Essential aspects of histocompatibility, preparative regimens used in stem cell transplantation, the use of hematopoietic growth factors and cytokines, the pathophysiology of the graft-versus-host reaction, and the management of complications are dealt with. This book should provide the practicing internist, pediatrician, hematologist, and oncologist as well as other physicians in training or in practice, physicians' assistants, nurses, and students with the information necessary to understand the concepts of stem cell transplantation and to include transplantation in the treatment planning soon after a diagnosis has been established. The text should also be useful to the physician who resumes the patients' care when they return from the transplant center


I. Pretransplant Considerations -- 1. Rationale and Indications for Transplantation -- 2. Timing of Transplantation -- 3. Stem Cell Sources -- 4. Preparation for Stem Cell Transplantation -- 5. Cost Considerations -- II. Transplant Procedure -- 1. Conditioning Regimens -- 2. Collection and Processing of Stem Cells -- 3. In Vitro Expansion of Stem Cells -- 4. Genetic Manipulation of Hematopoietic Stem Cells -- 5. Prevention and Treatment of Relapse -- III. Transplant-Related Problems -- 1. Side Effects of Conditioning Regimens -- 2. Graft Failure -- 3. Graft-Versus-Host Disease -- 4. Management of Infections -- 5. Single and Multi-Organ Failure -- 6. Chronic Graft-Versus-Host Disease -- 7. Delayed Complications -- IV. Long-Term Follow-Up -- 1. Follow-Up After Discharge from the Transplant Center -- 2. Rehabilitation -- QuoVadis? -- 225

Medicine Hematology Oncology Surgical transplantation Medicine & Public Health Hematology Oncology Transplant Surgery


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