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AuthorCohen, Margo Panush. author
TitleDiabetes and Protein Glycosylation [electronic resource] : Measurement and Biologic Relevance / by Margo Panush Cohen
ImprintNew York, NY : Springer New York, 1986
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Descript XII, 140p. 32 illus. online resource


In the years since the initial discovery that blood from diabetic patients contains increased amounts of a posttranslationally glucoยญ sylated form of hemoglobin (hemoglobin Ale)' an impressive number of studies have clarified and expanded the use of glycohemoglobin levels to assess disease status. Many other structural proteins have been shown to undergo similar changes, including proteins from tissues most commonly affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). Thus, the nonenzymatic glycosylation of hemoglobin emerges as an invaluable model for the pathogenesis of certain chronic diabetes complications. In addition to reviewing a wealth of investigative possibilities in the area of these chronic complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen indicates how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for maintenance of long-term euglycemia. Dr. Cohen is an endocrinologist and diabetes specialist whose research activities have largely focused on the chemistry and metaboยญ lism of the basement membrane in diabetes. This superb monograph on nonenzymatic glycosylation clearly shows the major trends of her past and present research and clinical activities. This book is beautifully written and a pleasure to read. It provides great insight into the mechanisms of the pathogenesis of the oom- vii viii Foreword cations of diabetes and should be of immense value not only to basic and clinical investigators, but also to internists, diabetologists, and endocrinologists in clinical practice


1. Introduction -- References -- 2. Chemistry -- Condensation of Glucose With Proteins -- Other Monosaccharides -- Modifying Factors -- Maillard Browning -- References -- 3. Measurement -- Circulating Proteins -- Tissue Proteins -- References -- 4. Clinical Use -- Monitoring Glycemic Control -- Diagnosis -- Pregnancy -- Complications of Diabetes -- References -- 5. Pathophysiologic Significance -- Blood Components -- Enzymes and Hormones -- Tissue and Structural Proteins -- Advanced Glycosylation End Products -- References

Medicine Endocrinology Metabolic diseases Biochemistry Medicine & Public Health Metabolic Diseases Biochemistry general Endocrinology


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