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TitleNovel Pharmacological Interventions for Alcoholism [electronic resource] / edited by Claudio A. Naranjo, Edward M. Sellers
ImprintNew York, NY : Springer New York, 1992
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Descript XV, 378 p. online resource


Novel Pharmacological Interventions for Alcoholism identifies priorities for focusing alcoholism and addiction research efforts during the coming years. A number of important issues concerning methodology, mechanisms, clinical evaluation, and pharmaceutical aspects are discussed. This book is also a plea for a greater degree of collaboration among academics, pharmaceutical physicians and scientists, and drug regulators; it demonstrates that progress in understanding and fighting addiction and alcoholism is possible in the foreseeable future


I. General Methodologic Issues -- 1. Animal Models for Testing Drug Effects on Alcohol Consumption -- 2. Animal Models for Screening Drugs to Decrease Alcohol Consumption -- 3. Medications for Alcohol Abuse and Dependence: Methodology for Clinical Studies -- 4. Some Issues in the Evaluation of a Pharmacotherapy of Alcoholism -- II. Serotonin and Alcohol Consumption -- 5. Serotonin and Alcohol Consumption -- 6. Serotonergic and Dopaminergic Involvement in Ethanol Intake -- 7. Serotonin and Alcohol Consumption -- 8. Basic and Clinical Studies on Serotonin, Alcohol, and Alcoholism -- 9. Evaluation of the Effects of Serotonin Uptake Inhibitors in Alcoholics: A Review -- III. Opioids and Alcohol Consumption -- 10. Opioids Modulate Ratsโ{128}{153} Propensities to Take Alcoholic Beverages -- 11. The Enkephalinergic System and Maintenance of Ethanol Drinking -- 12. The Relationship of Alcohol Drinking and Endogenous Opioids: The Opioid Compensation Hypothesis -- 13. Naltrexone in the Treatment of Alcohol Dependence: Preliminary Findings -- IV. The Role of Other Neurotransmitters in Regulating Alcohol Intake -- 14. Neurotransmitter Systems Regulating Alcohol Intake -- 15. Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal -- 16. Management of Alcohol Consumption with Angiotensin Converting Enzyme Inhibitors: A Review of the Animal Findings -- 17. Enalapril Does not Decrease Alcohol Intake in Normotensive Alcoholics -- Poster Papers -- General Methodologic Issues -- Rational vs. Reflexive Alcohol Drinking -- Ratsโ{128}{153} Intakes of Different Alcoholic Beverages -- Drug-induced Specific and Nonspecific Changes in Voluntary Ethanol Intake by Rats -- Rationale for Alcoholism Treatment Based on Inhibition of Aldehyde Dehydrogenase -- The Effect of Low Alcohol Beverages on Alcoholism Levels in Canada in 1986 -- Alcoholism, Antisocial Behavior, and Family History: A Synopisis -- Perception of Whether Drug or Placebo has been Administered is a Determinant of Drinking Reduction -- Disulfiram Treatment of Alcoholism -- Controlled Release Disulfiram (DS) Implant -- Depot Disulfiram: Pharmacokinetics and Clinical Effects During 28 Days Following a Single Subcutaneous Dose -- Mildly Intoxicating Levels of Alcohol Produces Direct Myocardial Depression on Left Ventricular Performance -- A Human Model for Testing Drug-induced Concomitant Variations in Alcohol Consumption and Desire to Drink -- Serotonin and Alcohol Consumption -- Mianserin, a Serotonergic Antagonist, and Intake of an Alcoholic Beverage -- Effects of the 5-HT Uptake Inhibitor, Sertraline, on Ethanol, Water and Food Consumption -- Fluvoxamine is Poorly Tolerated by Alcoholics -- Opioids and Alcohol Consumption -- Effects of Differential Handling on Ratsโ{128}{153} Intake of Alcohol -- Stereoselectivity of Opioidsโ{128}{153} Effects on Intake of an Alcoholic Beverage -- Metabolites of Morphine and Intake of an Alcoholic Beverage -- Peripheral Administrations of TIQS and Intake of an Alcoholic Beverage -- Morphine Enhances Intake of an Alcoholic Beverage Regardless of Type of Flavoring -- LY78335, an Inhibitor of Phenylethanolamine N-methyltransferase, and Ratsโ{128}{153} Intake of an Alcoholic Beverage -- LY255582, an Opioid Antagonist, and Intake of an Alcoholic Beverage -- Effects of Naltrexone on the Cognitive Functioning of Recently Abstinent Alcohol Dependent Patients -- The Role of Other Neurotransmitters in Regulating Alcohol Intake -- Calcium-diacetyl-homotaurinate which Prevents Relapse in Weaned Alcoholics Decreases the Action of Excitatory Amino Acids in Neocortical Neurons of the Rat in Vitro -- THC, an Active Ingredient in Marijuana, and Ratsโ{128}{153} Intake of a Sweetened Alcoholic Beverage -- Cocaine and Ratsโ{128}{153} Intake of an Alcoholic Beverage -- Calcium-acetylhomotaurinate for Maintaining Abstinence in Weaned Alcoholic Patients: A Placebo-controlled Double-blind Multicenter Study -- Effects of Angiotensin Converting Enzyme Inhibitors on Free Choice Ethanol Consumption by Rats -- Calcium Channel Antagonists Attenuate the Alcohol Dependence Syndrome -- Pharmacological Antagonism of Ethanol by Dl-?-tocopherol -- Characterization of DSM-IIIr Criteria for Uncomplicated Alcohol Withdrawal: Proposal for a Diagnostic Inventory and Revised Withdrawal Scale -- Ethanol Effects of CNS Dopamine Receptors: In vivo Binding Following Voluntary Ethanol (ETOH) Intake in Rats -- Closing Remarks -- Author Index

Medicine Pharmacology Psychiatry Psychology Medicine & Public Health Psychiatry Psychology general Pharmacology/Toxicology


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