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AuthorGaloyan, Armen A. author
TitleBrain Neurosecretory Cytokines [electronic resource] : Immune Response and Neuronal Survival / by Armen A. Galoyan
ImprintBoston, MA : Springer US : Imprint: Springer, 2004
Connect tohttp://dx.doi.org/10.1007/978-1-4419-8893-5
Descript VIII, 188 p. online resource

CONTENT

1 Neurosecretion of Cytokines by N. Paraventriculars and N. Supraopticus of Hypothalamus -- 1.1 The Isolation of Neurosecretory Granules from Bovine Hypothalamus and Neurohypophysis: Bio Assay Methods of Cytokine Identification -- 1.2 Identification of interleukins 1? and 1? in the Lysates of Neurosecretory Granules of Bovine Neurohypophysis and Hypothalamus -- 1.3 Identification of IL-2 in the Neurosecretory Granules of Bovine Neurohypophysis and Hypothalamus -- 1.4 Identification of IL-6 in the Neurosecretory Granules of Bovine Neurohypophysis -- 1.5 Identification of Tumor Necrosis Factor ? (TNF-?) in the Neurosecretory Granules of Bovine Hypothalamus and Neurohypophysis -- 2 Discovery of New Neurosecretory Cytokines: Proline-Rich Peptides Produced by N. Paraventricularis and N. Supraopticus of Hypothalamus -- 2.1 Isolation of Proline-Rich Peptides from the Neurosecretory Granules of Bovine Neuro-Hypophysis: Primary Structures, Mass-Spectral Characteristics, and Localization -- 2.2 Identification of PRP-1 in the Brain by Immunohistochemical Methods using Polyclonal Antibodies -- 2.3 Determination of PRP-1 in the Thymus, Lymph Nodes, and Heart using Monoclonal Antibodies -- 2.4 Interactions of PRP-1 with Coagulation Cascade Components : A Potential Role For PRP-1 in the Metabolism of Factor Xa/Antithrombin Iii Complex -- 3 interaction of PRP-1 with Cytokines, Hormones, and Neurotransmitters -- 3.1 Effect of PRP-1 and Lysates of Neurosecretory Granules on the Expression of Cytokines in Macrophages and Astrocytes -- 3.2 Effect of PRP-1 on the Expression of interleukins and Prolactin in Different Organs of Mice during Aluminum Neurotoxicosis -- 3.3 PRP-1 increases the Expression and Release of Human Growth Hormone in the Culture of Balb/C Mouse Fibroblasts -- 4 Antibacterial and Antiviral Activity of PRP-1 and Some Immunological Mechanisms of its Action -- 4.1 Effects of PRP-1 on the Survival of Mice infected with Different Strains of Gram-Negative and Gram-Positive Bacteria At Lethal Doses -- 4.2 Effects of PRP-1 on the Growth of Bacteria in the internal Organs of Mice infected with S. typhimurium -- 4.3 Effects of PRP-1 on Anti-Microbial Antibody Production in Mice infected with S. typhimurium and S. cholerae suis in Lethal Doses -- 4.4 Effect of PRP-1 on Bactericidal Activity of Macrophages -- 4.5 Effect of PRP-1 on the Secretion of Interleukin-1 by Peritoneal Macrophages of Mice infected with S. typhimurium in Sublethal Doses -- 4.6 Effect of PRP-1 on the Antigen-Presenting Function of Macrophages in Mice infected with S. typhimurium -- 4.7 Effect of PRP-1 on the Accumulation of Macrophages in Peritoneal Cavities of Mice infected with S. typhimurium -- 4.8 Effect of PRP-1 on the Viability of Macrophages in Mice infected with S. typhimurium -- 4.9 Effect of PRP-1 on interferon-? (IFN-?) Biosynthesis in Human Mononuclear Cells and the Replication of Encephalomyocarditis Virus in Cell Culture -- 5 Prp Regulation of T-Lymphocyte Development and Myelopoiesis -- 5.1 Influence of PRP-1 on interleukin-2-Dependent Functions of Human Lymphocytes in Culture and on the Proliferation of Jurkat Cells -- 5.2 Regulation of Thymocyte Differentiation by PRP-1 in Neonatal and Fetal Thymus -- 5.3 PRP-1 Is a Regulator of Myelopoiesis -- 6 Neuroprotective (Antineurodegenerative) Properties of PRP-1 -- 6.1 Protective Effect of PRP-1 Against Snake Venom- induced Neuronal injury -- 6.2 Protective Effect of PRP-1 Against Trauma- induced Central and Peripheral Neuronal injury -- 6.3 Morphological and Biochemical Changes in Brain Microstructure in Crush Syndrome and Effect of Prp -- 6.4 PRP-1 Protects Brain Neurons Against Aluminum (Al) Neurotoxicosis (Electron Microscopy Studies) -- 7 Effect of PRP-1 on Tumor Cells -- 7.1 Effect of PRP-1 on the Morphology and Mitotic Activity of Neurinoma of Rat Noduli Gasser (NRNG) Cells in Culture (Electron Microscopy Studies) -- 7.2 Changes in the Ultrastructure of L929 Tumor Cells Under the Action of PRP-1 in Vitro -- 8 Basic Biochemical Mechanisms of PRP-1 Action in Different Pathologies -- 8.1 Effect of PRP-1 on GFAP Biosynthesis in Astrocyte Culture (Immunocytochemical Data) -- 8.2 Effect of PRP-1 on Caspase Activity of Murine Neuroblastoma N2A -- 8.3 Regulation of Membrane Phospholipid Metabolism by PRP-1 in Cardiopulmonary insufficiency -- 8.4 Influence of PRP-1 on Consequences of Ionizing Irradiation in Rats -- Discussion -- Summary -- References -- List of abbreviations -- Acknowledgements


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