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TitleTarget validation in drug discovery [electronic resource] / editors, Brian W. Metcalf and Susan Dillon
Imprint Amsterdam ; Boston : Academic Press, c2007
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Descript xii, 279 p. : ill. ; 27 cm


This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book


Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches

Drug development Drugs -- Testing High throughput screening (Drug development) Drug Design Drug Delivery Systems Technology Pharmaceutical Mโedicaments -- Dโeveloppement Mโedicaments -- Essais cliniques Criblage แa haut dโebit (Dโeveloppement des mโedicaments) Electronic books.


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